Products

Guiding Documents:

 

Book Chapters:

  • Lofgren, E.T. & Fefferman, N.H. (2026). Outbreak in Orgrimmar: Corrupted Blood and the Epidemiology of Azeroth. The Psychgeist of Pop Culture: World of Warcraft. [Under Review]

Publications:

2026

  • Hasenjager, M.J., Bailey, M.M., & Fefferman, N.H. (2026). Group composition influences diffusion dynamics via impacts on behavioural production. Animal Behaviour, 233(C), 123482. https://doi.org/10.1016/j.anbehav.2026.123482
  • Jang, G., Candan, K.S., & Chowell, G. (2026). A comparative study of simulation-based inference methods for epidemic models with identifiability considerations. PLOS Computational Biology.
  • Karami, H., Anton, J.R., Jang, G., Candan, K.S., & Chowell, G. (2026). Adaptive COVID-19 Trajectory Forecasting Using Reinforcement-Learning Ensembles. International Journal of Forecasting.
  • Malinzi, J. & Dubey, P. (2026). Editorial: Integrative mathematical models for disease, volume II. Frontiers in Applied Mathematics and Statistics, 12. https://doi.org/10.3389/fams.2026.1843851
  • Mandal, P., Gorantla, A., Candan, K.S., & Sapino, M.L. (2026). Causal Search for Skylines (CSS): Causally-Informed Selective Data De-Correlation. Proceedings of the ACM on Management of Data, 4(3), 1–27. https://doi.org/10.1145/3802026
  • Anton, J.R., Sapino, M.L., & Candan, K.S. (2026). Gradient Guided Parameter Space Sampling for Knowledge Discovery With Limited Budgets. IEEE Access, 14, 53958–53977.
  • Silk, M.J. & Fefferman, N.H. (2026). Multilayer contagions in animal groups. Animal Behaviour, 235(C), 123525. https://doi.org/10.1016/j.anbehav.2026.123525
  • Sisk, A., Silk, M.J., Williams, N.D., & Fefferman, N.H. (2026). A typology of rules for knowledge exchange in higher-order interactions. PLOS Complex Systems, 3(1), e0000080. https://doi.org/10.1371/journal.pcsy.0000080

2025

  • Azad, F.T., Candan, K.S., & Chowell-Puente, G. (2025). Domain Disentanglement for Epidemic Onset Forecasting: Knowledge Transfer from Data-Rich to Data-Poor Communities. SSRN Electronic Journal.
  • Bleichrodt, A., Bourouiba, L., Chowell, G., Lofgren, E.T., Reed, J.M., Ryan, S.J., & Fefferman, N.H. (2025). Assembling ensembling: An adventure in approaches across disciplines. PLOS Computational Biology.
  • Bohon, S.A. & Hodges, S. (2025). Digging into Indigenous History. Contexts, 24(3), 34–39. https://doi.org/10.1177/15365042251377360
  • Flory, S.L., Ryan, S.J., Taneja, Y., Munoz, M., Lippi, C., & Allan, B. (2025). Impacts of plant invasions on tick-borne disease risk. BioScience.
  • Lippi, C.A., Poh, K.C., Mertins, J.W., Aldred, J., Bonilla, D., James, A.M., & Ryan, S.J. (2025). Exotic Tick (Ixodida: Ixodidae) Records for Florida: A Summary of Opportunistic Reporting. USDA.
  • McAlister, J.S., Brunner, J.L., Galvin, D.J., & Fefferman, N.H. (2025). A game theoretic treatment of contagion in trade networks. PLOS Computational Biology, 21(12), e1013845. https://doi.org/10.1371/journal.pcbi.1013845
  • Miller, D.L., Gibson, N.L., Ryan, S.J., Bourouiba, L., He, Q., Pasquale, D.K., Blum, M.J., Fefferman, N.H., Papeș, M., & Verheyen, C. (2025). Identifying outbreak risk factors through case-controls comparisons. Communications Medicine, 5(1). https://doi.org/10.1038/s43856-025-00916-5
  • Nuritdinov, F., Woo, J., Schmidt, M.J., Odjourian, N.M., Cristaldo, M., Dougher, M., Antilus-Sainte, R., Heldt, T., Rhee, K., Bourouiba, L., & Gengenbacher, M. (2025). Experimental system enables studies of Mycobacterium tuberculosis during aerogenic transmission. mBio, 16(10). https://doi.org/10.1128/mbio.00958-25
  • Pritchard, A.J., Silk, M.J., Young, M.J., & Fefferman, N.H. (2025). Evolution, Sociality, and Risk-taking.
  • Shen, N. & Bourouiba, L. (2025). Assessing bias in susceptible–infected–recovered estimation from aggregated epidemic data. Royal Society Open Science, 12(7). https://doi.org/10.1098/rsos.240526
  • Thunström, L., Ashworth, M., Cherry, T., Fefferman, N.H., Finnoff, D., Newbold, S., & Shogren, J.F. (2025). Demand for COVID-19 antiviral treatments and the role of primary care physicians.
  • Wright, J., McAlister, J., Almeida, R., Bletz, M., Gray, M., Lockwood, J., Masecar, S., Piovia-Scott, J., Warwick, A., & Fefferman, N.H. (2025). Trade Network BioSurveillance Strategies. Ecosphere.

2024

  • Reed, J.M., Candan, K.S., Miller, D.L., Bromberg, Y., Schreiner, C., Fefferman, N.H., Blum, M.J., He, Q., McAlister, J.S., Szabo-Rogers, H., & Lofgren, E. (2024). An interdisciplinary perspective of the built-environment microbiome. FEMS Microbiology Ecology, 101(1). https://doi.org/10.1093/femsec/fiae166

Preprints:

  • Biswas, P., Pedrielli, G., & Candan, K.S. (2026). Causality by Abstraction: Symbolic Rule Learning in Multivariate Timeseries with Large Language Models. CoRR abs/2602.17829. https://doi.org/10.48550/arXiv.2602.17829
  • Ryan, S.J., Lippi, C., & Meredith, J. (2026). Pandemic prediction in the space age: Use of earth observation system (EOS) data. https://doi.org/10.22541/essoar.15005880/v1
  • Dadlani, R., McAlister, J.S., Schwarze, A.C., Kawakatsu, M., Iams, S., Eissa, T.L., & Fefferman, N.H. (2026). Planned behavior, perceptual biases, and the dynamics of collective action.
  • Lavelle, T.E., Sánchez, C.A., Andrijevic, M., Becker, D.J., Gibb, R., Gonsalves, G.S., O'Donoghue, Z., Pachauri, S., Pereira, L.M., Poisot, T., Ryan, S.J., Seifert, S.N., Whittaker, C., & Carlson, C.J. (2026). Pandemic risk in the Shared Socioeconomic Pathways.
  • Lofgren, E.T., Myers, K., & Fefferman, N.H. (2026). When is Enough Enough? A Proposed Termination Point for the Number of Replicates in Computational Simulations.
  • Mark, M., Maslo, B., & Fefferman, N.H. (2026). Explicitly Incorporating Indirect Transmission Alters Predicted Disease Dynamics: A Scavenging-Based Extension of Classical Epidemiological Models.
  • Rieb, C.S., Goodrich-Blair, H., Miller, D.L., Udiani, O., & Fefferman, N.H. (2026). Community disease prevalence and building topology contribute to occupant exposure risk: A multilevel modeling approach.

Conference Abstracts:

2026

  • Lofgren, E.T. & Fefferman, N.H. (2026). Revisiting Corrupted Blood: Games and Contagion. NordMedia Conference, University of Southern Denmark.
  • Mehrotra, S. & Candan, K.S. (2026). Challenges in Sustaining Data Management Research in the GenAI Era. SIGMOD Companion '26: Companion of the International Conference on Management of Data, pp. 546–547. https://doi.org/10.1145/3788853.3801873

2025

  • Biswas, P., Pedrielli, G., & Candan, K.S. (2025). PYSIRTEM: An Efficient Modular Simulation Platform for the Analysis of Pandemic Scenarios. 2025 Winter Simulation Conference.
  • Kapkı, A., Mandal, P., Gorantla, A., Wan, S., Çoban, E., Sheth, P., Liu, H., & Candan, K.S. (2025). CausalBench: Causal Learning Research Streamlined. ACM KDD '25.

Poster Presentations:

2025

  • Misterka, M. & Bourouiba, L. (2025). Mean-Field Epidemic Models: Effect of Indirect Transmission. Internal MIT Student Poster Presentation.
  • Schreiner, C.L., Goodrich-Blair, H., He, Q., Li, S., Miller, D., Sisk, A., Udiani, O., & Fefferman, N.H. (2025). Building exposure risk: a multi-level modeling approach. Ecology and Evolution of Infectious Diseases (EEID) Annual Meeting.
  • Sullens, M. (2025). [Poster title not specified]. Conference on Complex Systems (CCS 2025).

Presentations:

2026

  • Bohon, S.A. & Hodges, S. (2026). Lessons Learned from Process Tracing with a Multidisciplinary Team. Annual Meeting of the Southern Sociological Society, Session 157, Jacksonville, FL.
  • Bohon, S.A. & Hodges, S. (2026). Slow Violence, Uncare, and the Nantucket Wampanoag. Annual Meeting of the Society for the Study of Social Problems, Session 70, New York, NY.
  • Okafor, C.C., Ayodo, C.O., Sham, M., Gass, J.D., & Lenhert, S. (2026). Advancing One Health Surveillance: Lessons from Case-Control Studies of Human Antimicrobial Resistance. International Congress on One Health, Saint-Quay-Portrieux, France.
  • Okafor, C.C., Ayodo, C.O., Sham, M., Gass, J.D., & Lenhert, S. (2026). Bridging Clinical Epidemiology and One Health: What U.S. Case-Control Studies Reveal About Human Antimicrobial Resistance. One Health: Antimicrobial Resistance and Emerging Zoonoses, Calgary, Alberta.
  • Okafor, C.C., Ayodo, C.O., Sham, M., Gass, J.D., & Lenhert, S. (2026). Where Is One Health in Human AMR Research? A Review of U.S. Case-Control Studies. National Institute of Antimicrobial Resistance Research and Education Conference, Ames, Iowa.
  • Schreiner, C.L., Stockmaier, S., & Fefferman, N.H. (2026). An underexplored theory for why culling has unintended consequences in social animals. Ecology and Evolution of Infectious Diseases 2026, Blacksburg, VA.

2025

  • APPEX Team. (2025). Mathematical modeling training session. North Africa Applied Systems Analysis Centre, IIASA/Institute of National Planning Egypt (virtual).
  • Bohon, S.A. & Hodges, S. (2025). Outbreak: Solving a 263-Year-Old Medical Mystery. Southern Demographic Association Annual Meetings, Lexington, KY.
  • Candan, K.S. (2025). Keynote: "The Power of 'Why?' in Decision Making in Complex, Dynamic Systems." 12th ACM International Conference on Multimedia Retrieval, Chicago, IL.
  • Fefferman, N. (2025). Keynote: Modeling Self-Organizing Networks in Life Sciences and Beyond. 18th Annual Symposium on Biomathematics & Ecology Education and Research, Fairfax, VA.
  • Fefferman, N. et al. (2025). APPEX perspectives, research, and Sandbox Simulation Toolkit. Duke University tutorial on "Social Networks and Health."
  • Lofgren, E. (2025). Gifts of the Grandfather: Warhammer's Plague Narratives from the Perspective of an Epidemiologist. Warhammer Conference 2025, Heidelberg, Germany.
  • McAlister, J. & Fefferman, N. (2025). Replicator Dynamics for Games on Networks. Complex Networks 2025, Binghamton, NY.
  • Strand, E. (2025). Invited guest presentation on Team Science and Community Engagement. UT Office of Community Engagement and Outreach Professional Development Seminar Series.
  • Strand, E.B. (2025). Team Science: Why and How. Community of Scholars for Resilient Agriculture and Forest Systems, University of Tennessee, Knoxville, TN.
  • Sullens, M. & Fefferman, N.H. (2025). Conceptualizing contagion: modeling complex contagion transmission with differential equations. Conference on Complex Systems, Siena, Italy.

Podcast/Media:

  • APPEX Researchers (4-Cutting Edge Ensemble Models researchers, 2 project teams). (2025). Podcasts about APPEX research and Pandemic Science. APPEX public media channels.

Public Exhibit:

  • Bourouiba, L. et al. (2024). Paradigm Shifts in Science: The History and Science of Epidemics and Germ Theory. MIT Institute for Medical Engineering and Science.

Software/Tools:

  • APPEX Team. (2025). Public-facing interactive infectious disease (SEIR) model simulator/dashboard. APPEX website.
  • Whitworth, C., Gorantla, A., Cui, X., Akpa, B., Bromberg, Y., Liu, H., & Candan, K.S. APPEX Metaannotation and Knowledge Synthesis. https://knowledgesynthesis.up.railway.app/login

Tutorials:

2026

  • Azad, F.T., Kapkiç, A., Mandal, P., Gorantla, A., Wan, S., Sapino, M.L., Liu, H., & Candan, K.S. (2026). Spatio-Causal Modeling and Applications. ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems.

2025

  • APPEX Team (Fefferman, N. et al.). (2025). What makes a useful model (virtual tutorial). Open/multi-institutional (35 registrants, 19 universities, 3 continents).
  • Candan, K.S. et al. (2025). CausalBench: Causal Learning Research Streamlined (tutorial on causal machine learning and epidemic applications). ACM SIGKDD International Conference on Knowledge Discovery and Data Mining.

Workshops:

2026

  • Bourouiba, L. et al. (2026). Fluids & Health: Viral Respiratory Disease Transmission Through the Air. Lorentz Center. https://www.lorentzcenter.nl/fluids-en-health-viral-respiratory-disease-transmission-through-the-air.html

2025

  • Tan, S.C., Gordon, K., Fefferman, N., & Strand, E.B. (2025). Team Science and Community Engagement. Advanced Community Engagement Seminar Series, University of Tennessee, Knoxville, TN.

 


For all work that results from your APPEX-related effort, please include the following acknowledgement: "This work was supported by NSF grant DBI 2412115 as part of the US NSF Center for Analysis and Prediction of Pandemic Expansion (APPEX)." Similarly, the NSF grant and APPEX Center should be acknowledged in all reports and interviews covering work related to your efforts as part of APPEX.


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This material is based upon work supported by the National Science Foundation under Award No. 2412115 and 2622265. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation