APPEX goes beyond existing research on disciplinarily targeted factors affecting pandemic risks and instead provides an enabling framework for synergy, complementing domain-driven research efforts. As such, APPEX ensures that the vision of pandemic science is proactive, focusing on framing how to meet complex challenges, improving both our ability to respond to existing disease threats and to be flexible, nimble, and adaptable to the next emerging pathogen we cannot yet anticipate to increase health security regionally, nationally, and globally.